Cullen Lab

2023

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• Gonzalez, B. Marti and Cullen, P.J. (IN PRESS) Heat shock proteins promote cell polarity during Cdc42p turnover and shield the protein from aggregation. Molecular and Cellular Biology

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2022

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• Gonzalez, B. and Cullen, P.J. (2022) Cdc42 turnover impacts the filamentation MAPK pathway in yeast Journal of Cell Biology 221(12):e202112100. doi: 10.1083/jcb.202112100. 

 

• Vandermeulen, M.D. and Cullen, P.J. (2022) Gene by Environment Interactions Reveal New Regulatory Aspects of Signaling Network Plasticity PLoS Genetics https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1009988.

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2021

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• Prabhakar, A., Gonzalez, B., Dionne, H., Basu, S. and Cullen, P.J. (2021) Spatiotemporal Control of Pathway Sensors and Cross-Pathway Feedback Regulate a Cell Differentiation MAPK Pathway in Yeast Journal of Cell Science Jul 9:jcs.258341. doi: 10.1242/jcs.258341. PMID: 34240741

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• The signaling network of the yeast NADPH oxidase Yno1p (2021) Weber, M. Basu, S., Gonzalez, B., Greslehner, G., Singer, S., Haskova, D., Hasek, J., Breitenbach, M., Gourlay, C., Cullen, P.J. *, and Rinnerthaler, M. * Antioxidants (Basel) 10(2):322. doi: 10.3390/antiox10020322

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2020

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• Jamalzadeh, S. Pujari, A.N. and Cullen, P.J. (2020) A Rab Escort Protein Regulates the MAPK Pathway That Controls Filamentous Growth in Yeast Scientific Reports 10(1) : 22184. doi: 10.1038/s41598-020-78470-4.

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• Patel, A., Abozeid, S., Cullen, P.J., and Morrow, J.  (2020) Co(II) macrocyclic complexes appended with fluorophores as paraCEST and cellCEST agents. Organic Chemistry

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• 53. Patel, A. Asic, D., Snyder, E., Spernyak, J.A., Cullen, P.J. and Morrow, J.R.  (2020) Saccharomyces cerevisiae and Candida albicans yeast cells labeled with  Fe(III) complexes as MRI probes Magnetochemistry

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• Slow growth and increased spontaneous mutation frequency in respiratory deficient yeast suppressed by a dominant mutation in ATP3. (2020) Li, J., Rinnerthaler, M., Hartl, J., Weber, M., Karl, T., Breitenbach-Koller, H., Mülleder, M., Vowinckel, J., Mattanovich, D., Sauer, M., Marx, H., Greslehner, G., Geltinger, F., Burhans, B., Grant, C., Doronina, V., Ralser, M., Streubel, K., Grabner, C., Jarolim, S., Moßhammer, C., Gourlay, C.W., Cullen, P.J. Liti, G., Ralser, M., and Breitenbach, M. G3: Genes Genomes Genetics 10(12):4637-4648. doi: 10.1534/g3.120.401537.

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• New Aspects of Invasive Growth Regulation Identified by Functional Profiling of MAPK Pathway Targets in Saccharomyces cerevisiae Vandermeulen, M.D. and Cullen, P.J. (2020) GENETICS doi: 10.1534/genetics.120.303369

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• Sho1p Connects Glycolysis to Ras1-cAMP Signaling and is Required for Microcolony Formation in Candida albicans (2020) Rohitashw Kumar, Malabika Maulik, Ruvini Pathirana, Cullen, P.J., and M. Edgerton mSPHERE 5(4):e00366-20. doi: 10.1128/mSphere.00366-20.

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• Binding and release of Fe(III) complexes from glucan particles for delivery of T1 MRI contrast agents (2020) Patel, A., Asik, D. Snyder, E.M., Delillo, A.E., Cullen, P.J., and Morrow, J.R. ChemMedChem 15(12):1050-1057. doi: 10.1002/cmdc.202000003.

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• Prabhakar, A., Chow, J., Siegel, A.J., and Cullen, P.J. (2020) Regulation of Intrinsic Polarity by a MAPK Pathway Journal of Cell Science pii: jcs.241513. doi: 10.1242/jcs.241513.

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• Basu, S., González, B., Li, B., Kimble, G., Kozminski, K.G. and Cullen, P.J. (2020) Functions for Cdc42p BEM Adaptors in Regulating a Differentiation-Type MAP Kinase Pathway. Molecular Biology of the Cell V31(6):491-510.

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2019

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• Chow J, Starr I, Jamalzadeh S, Muniz O, Kumar A, Gokcumen O, Ferkey DM, Cullen PJ. Filamentation Regulatory Pathways Control Adhesion-Dependent Surface Responses in Yeast. Genetics. 2019 May 3;. doi: 10.1534/genetics.119.302004. [Epub ahead of print] PubMed PMID: 31053593. 

 

• Chow J, Dionne HM, Prabhakar A, Mehrotra A, Somboonthum J, Gonzalez B, Edgerton M, Cullen PJ. Aggregate Filamentous Growth Responses in Yeast. mSphere. 2019 Mar 6;4(2). doi: 10.1128/mSphere.00702-18. PubMed PMID: 30842272; PubMed Central PMCID: PMC6403458. 

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• Nair SK, Basu S, Sen B, Lin MH, Kumar AN, Yuan Y, Cullen PJ, Sarkar D. Colloidal Gels with Tunable Mechanomorphology Regulate Endothelial Morphogenesis. Scientific Reports 2019 Jan 31;9(1):1072. doi: 10.1038/s41598-018-37788-w. PubMed PMID: 30705322; PubMed Central PMCID: PMC6355882.

 

2018

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• Sehgal, N.,  Sylves, M.E., Sahoo, A., Chow, J., Walker, S., Cullen, P.J, and Berry, J.O. (2018) CRISPR gene editing in yeast: An experimental protocol for an upper-division undergraduate laboratory course. Biochemistry and Molecular Biology Education

 

• Michael Breitenbach, Mark Rinnerthaler, Manuela Weber, Hannelore Breitenbach- Koller, Thomas Karl, Paul Cullen, Sukanya Basu, Dana Haskova, Jiri Hasek (2018) The defense and signaling role of NADPH oxidases in eukaryotic cells Wien. Med. Wochenschr. 168: 286-299.

 

• Chow, J., Notaro, M., Prabhakar, A., Free, S.J., and Cullen, P.J. (2018) Impact of Fungal MAPK Pathway Targets on the Cell Wall Journal of Fungi V4:93.

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• Norman, K.L, Shively, C.A., De La Rocha, A.J., Basu, S., Cullen, P.J., and Kumar, A. (2018) Inositol Polyphosphates Regulate and Predict Yeast Pseudohyphal Growth Phenotypes PLoS Genetics 14(6):e1007493.

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• González, B., Vázquez, J., Cullen, P.J, Mas, A., Beltran, G., Torija, M.J. (2018) Aromatic amino acid-derived compounds induce morphological changes and modulate the cell growth of wine yeast species. Frontiers of Microbiology V9:670.

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2017

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• Kumar, R., Breindel, C., Saraswat, D., Cullen, P.J., and M. Edgerton (2017) Candida albicans Sap6 amyloid regions function in cellular aggregation and zinc binding, and contribute to zinc acquisition. Scientific Reports

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• Gonzalez, B. Mas, A., Beltran, G., Cullen, P.J., Torija, M.J. (2017) Retrograde Mitochondria Pathway Regulates Ethanol-Inducible Filamentous Growth in Yeast Frontiers in Physiology 8:148. doi: 10.3389/fphys.2017.00148. 

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2016

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• Woolford, C.A., Lagree, K., Xu, W., Aleynikova, T., Adhikari, H., Sanchez, H., Cullen, P.J., Lanni, F., Andes, D.R., and AP Mitchell (2016) Biofilm formation in the absence of Candida albicans biofilm transcriptional activators. PLoS Genetics DOI:10.1371/journal.pgen.1006487.

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• Basu, S., Vadaie, N., Pradhakbar, A. Li, B., Pitoniak, A., Adhikari, H., Chavel, C., and Cullen, P.J. (2016) Spatial Landmarks Regulate a Cdc42p-Dependent MAPK Pathway to Control Differentiation and the Response to Positional Compromise. PNAS. 113(14):E2019-28.

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• Saraswat, D. Kumar, R., Pande, T. Edgerton M. and Cullen, P.J. (2016) Signaling Mucin Msb2 Regulates Adaptation to Thermal Stress in Candida albicans. Mol. Microbiology 100(3):425-41.

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• Cullen, P.J. and Edgerton M. (2016) Unmasking Fungal Pathogens by Studying MAPK-Dependent Cell Wall Regulation in Candida albicans. Virulence Apr 18:1-4.

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2015

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• Adhikari, H., Caccamise, L.M., Pande, T., and Cullen, P.J (2015) Comparative Analysis of Transmembrane Regulators of the Filamentous Growth MAPK Pathway Uncovers Functional and Regulatory Differences. Eukaryotic Cell 14(9):868-883.

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• Adhikari, H. Vadaie, N., Chow, J., Caccamise, L.M., Chavel, C.A., Li, B., Bowitch, A. Stefan, C.J., and Cullen, P.J. (2015) Role of the Unfolded Protein Response in Regulating the Mucin-Dependent Filamentous-Growth Mitogen Activated Protein Kinase Pathway. Molecular and Cellular Biology 35(8):1414-32.

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• Adhikari, H. and Cullen, P.J. (2015) Role of Phosphatidylinositol Phosphate Signaling In the Regulation of the Filamentous Growth MAPK Pathway. Eukaryotic Cell 14(4): 427-40.

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• Li, R. Puri, S. Tati, S. Cullen, P.J. and Edgerton, M. (2015) Candida albicans Cek1 MAPK signaling enhances fungicidal activity of salivary Histatin. Antimicrobial Agents and Chemotherapy 59(6):3460-8.

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• Pitoniak A., Chavel C.A., Chow J., Smith J., Camara D., Karunanithi S., Li B., Wolfe K., Cullen P.J. (2015) Cdc42p-Interacting Protein Bem4p Regulates the Filamentous Growth MAP Kinase Pathway. Mol. Cell. Biol. Nov 10. pii: MCB.00850-14.

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2014

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• Chavel C.A., Caccamise L.M., Li B., Cullen P.J. (2014) Global regulation of a differentiation MAPK pathway in yeast. Genetics V198(3):1309-28.

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• Adhikari, H. and Cullen P.J. (2014) Metabolic respiration induces AMPK- and Ire1p-dependent activation of the p38-Type HOG MAPK pathway. PLoS Genetics V10(10):e1004734. doi: 10.1371/journal.pgen.1004734.

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2012

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• Puri, S., Kumar, R., Chadha, S., Tati S., Conti, H.R., Hube, B., Cullen, P.J, Edgerton M. (2012) Secreted Aspartic Protease Cleavage of Candida albicans Msb2 Activates Cek1 MAPK Signaling Affecting Biofilm Formation and Oropharyngeal Candidiasis. PLoS ONE 7(11):e46020.

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• Karunanithi S., and Cullen P.J. (2012) The Filamentous Growth MAPK Pathway Responds to Glucose Starvation Through the Mig1/2 Transcriptional Repressors in Saccharomyces cerevisiae. Genetics 192(3):869-87.

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• Meem M.H. and Cullen P.J. (2012) The impact of protein glycosylation on Flo11-dependent adherence in Saccharomyces cerevisiae. FEMS Yeast Research 12(7):809-18.

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• Karunanithi S, Joshi J, Chavel C, Birkaya B, Grell L, and P.J. Cullen (2012)Regulation of Mat Responses by a Differentiation MAPK Pathway in Saccharomyces cerevisiae. PLoS ONE 7(4): e32294.

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• Cullen, P.J. and G.F. Sprague (2012) The regulation of filamentous growth in yeast. Genetics V190:23-49.

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2011

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• Cullen, P.J. (2011) Post-translational Regulation of Signaling Mucins. Current Opinion of Structural Biology V21 p590-596.

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2010

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• Karunanithi, S., Vadaie, N., Chavel, C., Birkaya, B., Joshi, J., Grell, L, and P.J. Cullen (2010) Shedding of the Mucin-like Flocculin Flo11p Reveals a New Aspect of Fungal Adhesion Regulation. Current Biology 20:1-7.

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• Chavel, C.A., Dionne, H.S., Birkaya, B. Joshi, J., and P.J. Cullen (2010) New Regulators of a Differentiation MAPK Pathway. PLoS Genetics 19; 6(3):e1000883.

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2009

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• Pitoniak, A., Birkaya, B., Dionne H.M., Vadaie, N., and P. J. Cullen (2009) The Signaling Mucins Msb2 and Hkr1 Differentially Regulate the Filamentation MAPK Pathway and Contribute to a Multimodal Response. Molecular Biology of the Cell V20 p3101-3114.

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• Birkaya, B. Maddi, A., Joshi, J., Free, S.J., and P.J. Cullen (2009) The Role of the Cell Wall Integrity Pathway and Cdc42-Dependent MAPK Pathway in Cell Wall Remodeling During Filamentous Growth. Eukaryotic Cell V8 p1118-1133.

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• Abdullah, U. and P.J. Cullen (2009) The tRNA Modification Complex Elongator Regulates the Cdc42-Dependent MAPK Pathway that Controls Filamentous Growth In Yeast. Eukaryotic Cell V8 p1362-1372.

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2008

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• Vadaie, N., Dionne, H., Nickerson, S.R., Akajagbor, D.S., Krysan, D.J., and Cullen, P.J. (2008) Cleavage of the signaling mucin Msb2 by the aspartyl protease Yps1 is required for MAPK activation in yeast. J. Cell Biology 181: 1073-1081.

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2007

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• Cullen, P.J. (2007) Signaling Mucins: The New Kids on the MAPK Block. Critical Reviews in Eukaryotic Gene Expression.

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2006

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• P.J. Cullen, Xu-Friedman, R., Delrow, J., and G. F. Sprague, Jr. (2006).Genome-wide analysis of a protein glycosylation deficiency. FEMS Yeast Research.

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2005 (Post-doctoral work with Dr. George Sprague)

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• Devit, M.J., Cullen, P.J. Branson, M., Sprague, G.F., and Fields, S. (2005).A novel genetic screening method based on artificially forced protein interactions. Genome Research 15 (4):560-565.

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2004

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• Cullen, P.J., Sabbagh Jr., W., Graham, E., Irick, M. van Olden, E.K., Neal, C., Delrow, J., Bardwell, L., and George F. Sprague, Jr. (2004). A signaling mucin at the head of the Cdc42- and MAPK-filamentous growth pathway in yeast.Genes & Development 18:1695-1708.

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• George F. Sprague, Jr., Cullen, P.J., and A. S. Goehring (2004) Yeast Signal Transduction: Regulation and Interface with Cell Biology. Adv. Exp. Med. Biol. 547:91-105.

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2002

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• Smith, G.R., Given, S.A., Cullen, P.J., and Sprague, G.F. (2002)Identification and Characterization of GTPase Activating Proteins (GAPs) for Cdc42. Eukaryotic Cell V1 p469-480. 

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• Cullen, P.J., and Sprague, G.F., Jr. (2002) The Glc7p-interacting protein Bud14p attenuates pheromone response, filamentous growth, and polarized growth in Saccharomyces cerevisiae. Eukaryotic Cell V1:884-894.

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• Cullen, P.J., and Sprague, G.F., Jr. (2002)The roles of bud-site-selection proteins in haploid invasive growth in yeast. Mol. Biol. Cell. 13:2990-3004.

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2000

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• Cullen, P.J. and Sprague, G.F. (2000) Glucose depletion causes haploid invasive growth in yeast. PNAS. 97: 13619-13624.*See Commentary on this article: Madhani, H.D. (2000) Interplay of intrinsic and extrinsic signals in yeast differentiation. PNAS 97: 13461-13463.

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• Cullen, P.J., Schultz, J., Horecka, J., Stevenson, B., and Jigami, Y., and Sprague, G.F. (2000) Defects in protein glycosylation cause SHO1-dependent activation of a STE12 signaling pathway in yeast. Genetics 155: 1005-1018.

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Prior to 2000 (PhD work with Dr. Robert Kranz)

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• Cullen, P.J., W.C. Bowman, S. Riley, Foster-Hartnett, D., and R.G. Kranz (1998) Translational activation by an NtrC enhancer-binding protein. J. Mol. Biol. 278: 903-914.

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• Cullen, P.J., Kauffman, C., and R.G. Kranz (1997) Characterization of the R. capsulatus housekeeping RNA polymerase: in vitro transcription of photosynthesis and other genes. J.Biol.Chem. 272: 27266-27273.

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• Cullen, P.J., Bowman, W. and R.G. Kranz (1996) In vitro reconstitution and characterization of the Rhodobacter capsulatus NtrB and NtrC two component system. J.Biol.Chem. 271:6530-6.

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• Foster-Hartnett, D., Cullen, P.J., E.M. Monika and R.G. Kranz  (1994) A new type of NtrC transcriptional activator. J.Bacteriology 176: 6175-6187.

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• Cullen, P.J., D. Foster-Hartnett, K.K. Gabbert, and R.G. Kranz. (1993) Structure and expression of the alternative sigma factor, RpoN, in Rhodobacter capsulatus; physiological relevance of an autoactivated nifU2-rpoN superoperon. Mol. Microbiol. 11: 51-65.

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• Foster-Hartnett, D., Cullen, P.J., Gabbert, and R.G. Kranz. (1993) Sequence, genetic, and lacZ fusion analyses of a nifR3-ntrB-ntrC operon in R. capsulatus.   Mol. Microbiol. 8: 903-14.

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• R.G. Kranz, Cullen, P.J., W. Bowman, and B. Goldman (1996) Proceedings of the Tenth International Photosynthesis Congress. Jonker, G. (ed) Kluwer Academic Publishers p1-6.

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• Kranz, R.G., and Cullen, P.J. (1995) Regulation of Nitrogen Fixation Genes. in Anoxygenic Photosynthetic Bacteria. Blankenship, R.E., Madigan, M.T., and Bauer, C. (eds.) Kluwer Academic Publishers p1191-1205.

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• Cullen, P.J., D. Foster-Hartnett, K. Gabbert, and R.G. Kranz (1992) New Horizons in Nitrogen Fixation. Palacios, R., J. Mora, and W.E. Newton (eds.) p.453-472.